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VM Donepezil

Visual representation of the interaction
Mode of action
Donepezil
Transporter zone
No interaction
Enzyme zone
Acetylcholinesterase
Butyrylcholinesterase
Receptor zone
No interaction
Ion channel zone
No interaction

NbN-2 donepezil

Molecular structure
NbN_library N O O O
Mode of action
enzyme inhibitor (acetylcholinesterase)
Pharmacological target
acetylcholine
Date published
05.01.2017

Donepezil

For more detailed explanation of the principles of the VM Library
For more detailed explanation of the Neuroscience based Nomenclature

Please notice that Caution should be applied when extrapolating animal data to humans.

Detailed and Approved Information on the clinical use of the compounds can be found at the homepage of EMA or at Martindale.

References
  1. Deardorff WJ, Feen E and Grossberg GT. (2015) The Use of Cholinesterase Inhibitors Across All Stages of Alzheimer's Disease. Drugs Aging 32: 537-547.
  2. Leinonen A, Koponen M and Hartikainen S. (2015) Systematic Review: Representativeness of Participants in RCTs of Acetylcholinesterase Inhibitors. PLoS One 10: e0124500.
  3. Luo W, Yu QS, Kulkarni SS, et al. (2006) Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. J Med Chem 49: 2174-2185.
  4. NbN-2 www.nbn2.com
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