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VM Sulpiride

Visual representation of the interaction
Mode of action
Sulpiride
Transporter zone
No interaction
Enzyme zone
No interaction
Receptor zone
Important for clinical effects
Ion channel zone
No interaction

NbN-2 sulpiride

Molecular structure
NbN_library S H 2 N O O O O N NH
Mode of action
receptor antagonist (D2)
Pharmacological target
dopamine
Date published
05.01.2017

Sulpiride

For more detailed explanation of the principles of the VM Library
For more detailed explanation of the Neuroscience based Nomenclature

Please notice that Caution should be applied when extrapolating animal data to humans.

Detailed and Approved Information on the clinical use of the compounds can be found at the homepage of EMA or at Martindale.

References
  1. Malmberg A, Jackson DM, Eriksson A, et al. (1993) Unique binding characteristics of antipsychotic agents interacting with human dopamine D2A, D2B, and D3 receptors. Mol Pharmacol 43: 749-754.
  2. Matsubara S, Matsubara R, Kusumi I, et al. (1993) Dopamine D1, D2 and serotonin2 receptor occupation by typical and atypical antipsychotic drugs in vivo. J Pharmacol Exp Ther 265: 498-508.
  3. Seeman P and Tallerico T. (1998) Antipsychotic drugs which elicit little or no parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors. Mol Psychiatry 3: 123-134.
  4. Terai M, Usuda S, Kuroiwa I, et al. (1983) Selective binding of YM-09151-2, a new potent neuroleptic, to D2-dopaminergic receptors. Jpn J Pharmacol 33: 749-755
  5. NbN-2 www.nbn2.com
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