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VM Flupenthixol

Visual representation of the interaction
Mode of action
Flupenthixol
Transporter zone
No interaction
Enzyme zone
No interaction
Receptor zone
Contributes to other effects
Contributes to other effects
Ion channel zone
No interaction

NbN-2 flupenthixol

Mode of action
receptor antagonist (D2, 5-HT2)
Pharmacological target
dopamine, serotonin
Date published
05.01.2017

Flupenthixol

For more detailed explanation of the principles of the VM Library
For more detailed explanation of the Neuroscience based Nomenclature

Please notice that Caution should be applied when extrapolating animal data to humans.

Detailed and Approved Information on the clinical use of the compounds can be found at the homepage of EMA or at Martindale.

References

Hill SJ and Young M. (1978) Antagonism of central histamine H1 receptors by antipsychotic drugs. Eur J Pharmacol 52: 397-399.

Mahapatra J, Quraishi SN, David A, et al. (2014) Flupenthixol decanoate (depot) for schizophrenia or other similar psychotic disorders. Cochrane Database Syst Rev: CD001470.

Reimold M, Solbach C, Noda S, et al. (2007) Occupancy of dopamine D(1), D (2) and serotonin (2A) receptors in schizophrenic patients treated with flupentixol in comparison with risperidone and haloperidol. Psychopharmacology (Berl) 190: 241-249.

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