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VM Asenapine

Visual representation of the interaction
Mode of action
Asenapine
Transporter zone
No interaction
Enzyme zone
No interaction
Receptor zone
Important for clinical effects
Contributes to other effects
Contributes to other effects
Important for clinical effects
Important for clinical effects
Important for clinical effects
Ion channel zone
No interaction

NbN-2 asenapine

Mode of action
receptor antagonist ( 5-HT2, D2, NE alpha-2)
Pharmacological target
serotonin, dopamine norepinephrine
Date published
08.02.2016

Asenapine

For more detailed explanation of the principles of the VM Library
For more detailed explanation of the Neuroscience based Nomenclature

Please notice that Caution should be applied when extrapolating animal data to humans.

Detailed and Approved Information on the clinical use of the compounds can be found at the homepage of EMA or at Martindale.

References
  1. Andree B, Halldin C, Vrijmoed-de VM, et al. (1997) Central 5-HT2A and D2 dopamine receptor occupancy after sublingual administration of ORG 5222 in healthy men. Psychopharmacology (Berl) 131: 339-345.
  2. Plosker GL and Deeks ED. (2016) Asenapine: A Review in Schizophrenia. CNS Drugs 30: 655-666.
  3. Shahid M, Walker GB, Zorn SH, et al. (2009) Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J Psychopharmacol 23: 65-73.
  4. NbN-2 www.nbn2.com
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