Synaptic Dopamine reuptake and degradation

Dopamine is released from the presynaptic terminal, diffuses over the synaptic cleft and activates Dopaminergic receptors (D1-D5 receptors). After release from the nerve terminal, Dopamine is taken up via a presynaptically located Dopamine transporter and degraded by the Mono amine oxidase B (MAO-B)

References
  1. Dopaminergic Signaling in Dendritic Spines. Yao WD, Spealman RD and Zhang J. Biochem Pharmacol. 2008 June 1; 75(11): 2055–2069
  2. Other Transmitters and Modulators. In: Rang & Dale’s Pharmacology 9th edition. Rang HP, Dale MM, Ritter JM and Gardner P. Edinburgh, UK: Harcourt Publishers Ltd, 2016:468–472
  3. Dopaminergic modulation of synaptic transmission in cortex and striatum. Tritsch NX and Sabatini BL. Neuron. 2012 October 4; 76(1): 33–50
  4. Noradrenergic transmission. In: Pharmacology, 4th edition. Rang HP, Dale MM, Ritter JM and Gardner P. Edinburgh, UK: Harcourt Publishers Ltd, 2001:139–163
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