The serotonin pathways in depression

Serotonin transmission from both the caudal raphe nuclei and rostal raphe nuclei is reduced in patients with depression compared with non-depressed controls. Increasing the levels of serotonin in these pathways, by reducing serotonin reuptake and hence increasing serotonin function, is one of the therapeutic approaches to treating depression.


Neural plasticity and disorders of the nervous system. In: Neuroscience at a glance, Barker RA and Barasi S with Neal MJ. London, England, 1999:105–121

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