Pramipexole

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Mode of action
Pramipexole
Transporter zone
No interaction
Enzyme zone
No interaction
Receptor zone
Contributes to other effects
Important for clinical effects
Ion channel zone
No interaction
References
  1. Fox SH, Katzenschlager R, Lim SY, et al. (2011) The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the motor symptoms of Parkinson's disease. Mov Disord 26 Suppl 3: S2-41.
  2. Kulisevsky J and Pagonabarraga J. (2010) Tolerability and safety of ropinirole versus other dopamine agonists and levodopa in the treatment of Parkinson's disease: meta-analysis of randomized controlled trials. Drug Saf 33: 147-161.
  3. Millan MJ, Maiofiss L, Cussac D, et al. (2002) Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J Pharmacol Exp Ther 303: 791-804.
  4. Newman-Tancredi A, Cussac D, Audinot V, et al. (2002a) Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D(2)-like receptor and alpha(1)/alpha(2)-adrenoceptor. J Pharmacol Exp Ther 303: 805-814.
  5. Newman-Tancredi A, Cussac D, Quentric Y, et al. (2002b) Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. III. Agonist and antagonist properties at serotonin, 5-HT(1) and 5-HT(2), receptor subtypes. J Pharmacol Exp Ther 303: 815-822.
  6. Seeman P. (2015) Parkinson's disease treatment may cause impulse-control disorder via dopamine D3 receptors. Synapse 69: 183-189.

For more detailed explanation of the principles of the VM Library

Please notice that Caution should be applied when extrapolating animal data to humans.

Detailed and Approved Information on the clinical use of the compounds can be found at the homepage of EMA or at Martindale.

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