Memantine

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Mode of action
Memantine
Transporter zone
No interaction
Enzyme zone
No interaction
Receptor zone
Important for clinical effects
Ion channel zone
No interaction
References
  1. Danysz W and Parsons CG. (2012) Alzheimer's disease, beta-amyloid, glutamate, NMDA receptors and memantine--searching for the connections. Br J Pharmacol 167: 324-352.
  2. Bond M, Rogers G, Peters J, et al. (2012) The effectiveness and cost-effectiveness of donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer's disease (review of Technology Appraisal No. 111): a systematic review and economic model. Health Technol Assess 16: 1-470.
  3. Matsuzono K, Yamashita T, Ohta Y, et al. (2015) Clinical Benefits for Older Alzheimer's Disease Patients: Okayama Late Dementia Study (OLDS). J Alzheimers Dis 46: 687-693.

For more detailed explanation of the principles of the VM Library

Please notice that Caution should be applied when extrapolating animal data to humans.

Detailed and Approved Information on the clinical use of the compounds can be found at the homepage of EMA or at Martindale.

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