Clozapine

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Mode of action
Clozapine
Transporter zone
No interaction
Enzyme zone
No interaction
Receptor zone
Contributes to other effects
Contributes to other effects
Important for clinical effects
Contributes to other effects
Important for clinical effects
Important for clinical effects
Important for clinical effects
Ion channel zone
No interaction
References
  1. Kroeze, W. K., S. J. Hufeisen, B. A. Popadak, S. M. Renock, S. Steinberg, P. Ernsberger, K. Jayathilake, H. Y. Meltzer and B. L. Roth (2003). "H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs." Neuropsychopharmacology 28(3): 519-526.
  2. Richelson, E. and T. Souder (2000). "Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds." Life Sci 68(1): 29-39.
  3. Uchida, H., H. Takeuchi, A. Graff-Guerrero, T. Suzuki, K. Watanabe and D. C. Mamo (2011). "Predicting dopamine D(2) receptor occupancy from plasma levels of antipsychotic drugs: a systematic review and pooled analysis." J Clin Psychopharmacol 31(3): 318-325.

For more detailed explanation of the principles of the VM Library

Please notice that Caution should be applied when extrapolating animal data to humans.

Detailed and Approved Information on the clinical use of the compounds can be found at the homepage of EMA or at Martindale.

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