Source (slide): 1. Ferrari et al. PLoS One 2013; 8 (7): e69637; page 9 (‘Final prevalence output’ section); 2. Ferrari et al. PLoS Med 2013; 10 (11): e1001547; page 5 (‘Direct burden of depressive disorders’ section); 3. WHO. The Global Burden of Disease 2004 update: page 50 (‘Halving the contribution of Group 1 causes‘ section) and Figure 27; 4. Vos et al. Lancet 2012; 380: 2163–2196; Figure 4.
Source (notes): Ferrari et al., PLoS One 2013 p9; Ferrari et al., PLoS Med 2013 p4/5; WHO, 2008 p50.
MDD has a worldwide prevalence of 4.4%, corresponding to 298 million people (estimate from 2010 Global Burden of Disease Study [GBDS]).(Ferrari et al., PLoS One 2013) Overall, prevalence is higher in females (5.5%) than in males (3.2%), corresponding to 187 million females and 111 million males worldwide.(Ferrari et al., PLoS One 2013) Prevalence peaks between the ages of 20 and 64 years; the highest number of prevalent cases is in the age group 25–34 years (57 million cases).(Ferrari et al., PLoS One 2013)
Disease burden can be compared across diseases and injuries using the ‘disability-adjusted life-year’ (DALY). One DALY represents the loss of one healthy year of life; it is the sum of the years of life lived with disability (YLD) and years of life lost due to premature mortality.(Ferrari et al., PLoS Med 2013) MDD accounts for 2.5% of global DALYs, making it the eleventh leading cause of disease burden worldwide (estimate from 2010 GBDS).(Ferrari et al., PLoS Med 2013) By 2030, unipolar depressive disorders including MDD are predicted to become the leading cause of DALYs (estimate from 2004 GBDS; not re-estimated following 2010 GBDS).(WHO, 2008) In terms of YLDs, MDD is the second leading cause of burden (accounting for 8.2% of global YLDs), after lower back pain (estimate from 2010 GBDS).(Ferrari et al., PLoS Med 2013)